Introduction::
Introduction: An abdominal aortic aneurysm (AAA), a deadly disease in elderly population is featured by the expansion of aortic diameter, degradation of extracellular cellular matrix (ECM) leading to weakening and inflammation in vasculature. We previously reported that intravenous targeted therapy of polyphenol Pentagalloyl glucose (PGG) regenerates damaged elastin and restores vascular cellular architecture in aneurysmal aorta (Dhital et al., 2020, Dhital et al., 2022). We reported that polyphenol therapy in mouse resulted in deactivation and decreased infiltration of macrophages, decrease in inflammatory cytokines production such as IL-6 and IFN-Y and induction of anti-inflammatory cytokine Il-10 in aneurysmal vasculature in mouse.









Materials and Methods::
Methods: We performed the standard collection of published reports and performed through review of those data with standard methods whichever is appropriate including meta-analysis. The data involved the peer-reviewed articles about the application of polyphenol in vitro, in vivo and review analysis. The tables, images, and concepts were analyzed with critical review.




Results, Conclusions, and Discussions::
Results and Discussions: Here, this report demonstrates the meta-analytic review outcomes of the mechanism of polyphenol led vascular extracellular cellular matrix regeneration and remodeling in in vitro and in vivo studies in different time points. Our findings demonstrates that the action of polyphenol to restore vascular architecture involves multiple pathways including endogenous damage-associated molecular pattern molecules and phosphorylated pathway (Lai CH et al., 2016). This study provides significant information for the therapeutical study of polyphenol against vascular damage.




Acknowledgements (Optional): :

References (Optional): :
References:




1: Dhital S, Vyavahare NR (2020) Nanoparticle-based targeted delivery of pentagalloyl glucose reverses elastase-induced abdominal aortic aneurysm and restores aorta to the healthy state in mice. PLoS ONE 15(3): e0227165. https://doi.org/10.1371/journal.pone.0227165




2: Dhital S, Rice CD, Vyavahare NR. Reversal of elastase-induced abdominal aortic aneurysm following the delivery of nanoparticle-based pentagalloyl glucose (PGG) is associated with reduced inflammatory and immune markers. Eur J Pharmacol. 2021 Nov 5;910: 174487. doi: 10.1016/j.ejphar.2021.174487. Epub 2021 Sep 10. PMID: 34516951; PMCID: PMC9372922.

3: Lai CH, Wang KC, Lee FT, Tsai HW, Ma CY, Cheng TL, et al. (2016) Toll-Like Receptor 4 Is Essential in the Development of Abdominal Aortic Aneurysm. PLoS ONE 11(1): e0146565.