Instructor
Brigham and Women's Hoapital, Harvard Medical School
I am, Dr. Tanmoy Saha (PhD), an Instructor at Harvard Medical School and an Investigator at Brigham and Women's Hospital. My overarching research goal is to use nanoscale technologies as a tool to understand different cellular mechanism of cancer and then design, develop, and deploy novel therapeutic agents and treatment strategies to target these mechanisms. For the last several years, I have been devoted to interdisciplinary research consisting of organic chemistry, drug delivery, cancer biology, nanotechnology, and immunotherapy. During my Ph.D. training, my work was related to trans-membrane cellular communication of ions (received the best thesis award from IISER Pune). I introduced artificial anion (Cl-) channels and carriers for successive transport of ions across the membrane and investigated the apoptosis-inducing capability by disrupting ionic homeostasis of cells (3 publications in J. Am. Chem. Soc). I extended my research to intracellular communication and its effect on on-disease progressions, like cancer. I investigated the new mechanism of immune evasion by mitochondria transfer (published in Nature Nanotechnology). I am also developing novel drug delivery systems and immunotherapy with targeting strategies for different chemoresistance cancers. Another work related to antibody nanoparticle conjugate to treat lung cancer patients is under revision in Science Advances, where I am serving as a corresponding author. Recently I have been awarded KCRP-PCRF grant on kidney cancer from the Department of Defense and a Young Investigator grant from the Melanoma Research Alliance. Currently, I am appointed as an Instructor, which is a junior faculty position at Harvard and BWH.