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    Biomedical Imaging and Instrumentation

    (G-265) The CathCam: A Solution for Endovascular Device Navigation Using Angioscopic Visualization

    Friday, October 13, 2023
    3:30 PM – 4:30 PM PDT
    Location: Exhibit Hall - Row G - Poster # 265
    Introduction:: Peripheral arterial disease (PAD) affects more than 200 million individuals worldwide and is primarily characterized by the narrowing or obstruction of arteries, commonly occurring in the lower extremities. The existing revascularization techniques for PAD have certain limitations, such as inadequate control over catheter tip movement and insufficient clarity of soft tissue under X-ray imaging. To overcome these limitations, a study was conducted to evaluate the effectiveness of the CathCam, a miniature angioscope integrated into the Cathpilot system, for catheter-based cardiovascular interventions.

    Materials and Methods:: The study comprised three components. Initially, the performance of the CathCam was compared to conventional catheters using 3D-printed phantom models. Subsequently, in an ex vivo setup, the device groups were evaluated by using four lesion samples of a chronic total occlusion (CTO) harvested from an amputated patient's superior femoral artery. The evaluation criteria included the success rate of guidewire crossing, crossing time, and fluoroscopy time. Finally, the safety and feasibility of the CathCam in visualizing arteries were assessed in vivo using a porcine model.

    Results, Conclusions, and Discussions::

    The results indicated that the CathCam achieved a 100% success rate in crossing 3D printed lesions in the phantom experiments and a 75% success rate in crossing CTO samples ex vivo. Conventional catheters only achieved success rates of 35% and 25% in the respective experiments. The average crossing time using the CathCam was significantly shorter (p< 0.0001, two-way ANOVA), at 31.68±27.65 seconds in the phantom experiments and 210±237.67 seconds in the ex-vivo experiments, compared to 502±170.82 seconds and 511.31±163.21 seconds with conventional catheters. Moreover, the in vivo experiment confirmed the safety and feasibility of the CathCam. In conclusion, the study demonstrated that CathCam can potentially increase the success rate of endovascular revascularization procedures while reducing crossing time and fluoroscopy time compared to conventional catheters. The findings underscore the potential of the CathCam which combines the means of accurate device positioning, steering, and support with simultaneous real-time visual angioscopy feedback.



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