Assistant Professor
Houston Methodist Research Institute, United States
My research centers on the function of endothelial cells and their progression into senescence, with a specific focus on progeria syndrome. Utilizing human HGPS induced pluripotent stem cells, their derivatives, and mouse models of HGPS, I delve deep into understanding the role of telomere erosion and, on a broader scale, DNA damage in vascular aging. My recent discoveries indicate a telomere-independent function of telomerase in repairing genomic DNA damage. This repair mechanism is, in part, mediated through interactions with splicing factors or lncRNA. A central goal of my scientific journey is to unravel the molecular mechanisms through which telomerase defends against DNA damage. I'm driven by the conviction that comprehending this mechanism could pave the way for innovative gene therapies targeting vascular senescence and cancer.
Cardiovascular Regeneration and Stem Cells
Friday, October 13, 2023
8:00 AM – 9:30 AM PDT
Reversal of DNA Damage-Induced Senescence in Endothelial Cells Using mRNA Telomerase
Friday, October 13, 2023
8:00 AM – 8:15 AM PDT