Skip to main content
2023 BMES Annual Meeting Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.

Cardiovascular Engineering

Innovations in cardiovascular biosensors and medical devices

Assessing Chemotherapy-induced Cardiotoxicity using a Fully Implantable Mechano-Acoustic Sensing Platform

Saturday, October 14, 2023
1:30 PM – 1:45 PM PDT
Location: 336 (Center, Level 3)
Introduction:: Introduction


Doxorubicin (DOX) is a chemotherapy drug with significant cardiotoxic effects. Continuous monitoring of cancer patients’ cardiovascular health and early detection of cardiotoxicity is currently an unmet clinical need. Fully implantable bioelectronic devices can continuously sense the variations in cardiac physiological parameters and wirelessly transmit the collected data for interpretation. As a physiological mechano-acoustic (MA) signal, seismocardiogram (SCG) measures the vibration induced by the heart’s mechanical contraction. This study investigated the acute DOX-induced cardiotoxicity in mice using a novel MA sensing device.


Materials and Methods:: Materials and Methods


MA sensing devices (12 mm in width, 35 mm in length) were implanted subcutaneously in the abdomen of the mice (C57BL/6J; 13-15 weeks old; male and female). Two weeks after the implantation surgery, mice were intraperitoneally injected with either 20 mg/kg DOX or saline (control group). SCG signals were collected from the MA device 6 hours, 12 hours, 24 hours, and 48 hours post-injection using wireless data acquisition platform. Concurrently, electrocardiograms (ECG) were recorded using ecgTUNNEL device (emka Technologies) from conscious mice, as a gold standard comparison. A custom MATLAB software was used to analyze the ECG and SCG data.


Results, Conclusions, and Discussions:: Results/Discussions

The SCGs data from MA device indicated a decreasing trend in heart rate (HR) at timepoints 6 hours, 12 hours, and 24 hours, while the HR was significantly reduced at 48 hours (HR = 615.7±19.7, p=0.04, n=4) after the DOX treatment compared to the baseline. ECG analysis revealed that RR intervals were prolonged at 6 hours (RR=87.7±3, p=0.04, n=4) post-DOX treatment versus baseline controls and this effect was sustained up to 48 hours post-injection. No significant changes in P, PR, QT and QRS intervals were observed up to 24 hours post-injection. Taken together, the SCG and ECG data both demonstrated similar cardiotoxic ECG response in terms of acute decrease in HR post-DOX injection.

Conclusions

This study for the first time utilizes wireless MA sensing to assess acute cardiotoxic response to DOX in mice. The novel SCG implantable platform does not restrict animal’s movement and offers the benefits of continuous monitoring in freely moving mice. This technology holds the promise for early diagnosis of chemotherapy-induced cardiotoxicity and wireless cardiovascular health monitoring.

Acknowledgements (Optional): :

References (Optional): :