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Biomaterials

Advances in Biomaterials and Bioinks: Innovations in 3D Bioprinting

A fully automated platform for photoinitiated RAFT polymerization of biomaterials

Friday, October 13, 2023
2:15 PM – 2:30 PM PDT
Location: 333 (Center, Level 3)
We developed a robotic platform to fully automate PET-RAFT polymerizations and provide individual control of reactions performed in 96-well plates. On our platform, reagents are automatically dispensed in well plates, photoinitiated in individual wells with a custom-designed lightbox until the polymerizations are complete, and monitored online in real-time by tracking fluorescence intensities on a fluorescence plate reader, with well plate transfers between instruments occurring via a robotic arm. This platform enabled robust parallel polymer synthesis of both acrylate and acrylamide homopolymers and copolymers, with high monomer conversions and low dispersity. The successful polymerizations obtained on this platform make it an efficient tool for combinatorial polymer chemistry.