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Biomanufacturing

Biomaterials/3D Printing

Performance micromachining for creation of well plate based microphysiological models

Thursday, October 12, 2023
8:30 AM – 8:40 AM PDT
Location: 333 (Center, Level 3)

    Presenting Author(s)

  • Jacob I. Reynolds (he/him/his)

    PhD Candidate
    Michigan State University
    East Lansing, Michigan, United States

    • Co-Author(s)

  • MA

    Meredith Adams

    College of Human Medicine, Michigan State University 15 Michigan St NE, Grand Rapids, Michigan, USA, United States

    • Primary Investigator(s)

  • BJ

    Brian Johnson, PhD

    Michigan State University
    Lansing, Michigan, United States


Microfluidic devices offer numerous advantages to cell culture applications but still face significant barriers to adoption by standard biological laboratories. To address the perceived challenge in microfluidic device fabrication and to offer a user-friendly format we create microfluidic devices via subtractive manufacturing of standard well plates. We demonstrate microplate micromilling for the creation of microphysiological models and provide demonstration of the creation of relevant microscale features using three different CNC mills of potential interest to biological laboratories looking to adopt this technology.