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Orthopedic and Rehabilitation Engineering

Bone

DMP1 Lineage Connexin43 Deficiency Attenuates Decreases in Skeletal Muscle Strength and Fracture Callus Mineralization During Hindlimb Unloading

Thursday, October 12, 2023
9:14 AM – 9:21 AM PDT
Location: 334 (Center, Level 3)
Preclinical studies have shown that musculoskeletal unloading by hindlimb suspension (HLU) decreases hindlimb bone and skeletal muscle mass and alters fracture healing similar to aging. Our results in the following presentation demonstrate that loss of Cx43, in mature osteoblasts and osteocytes but not skeletal muscle cells, attenuates HLU induced decreases in skeletal muscle weakness and impaired fracture callus mineralization in vivo. These findings are novel, exciting, and suggest altered mechanosensation of skeletal muscle and callus tissues with loss of Cx43 that warrants further mechanistic study.