Skip to main content
2023 BMES Annual Meeting Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Back

    Tissue Engineering

    (H-309) Breast Tissue Reconstruction Using Polycaprolactone Ball Scaffolds in a Partial Mastectomy Pig Model

    Thursday, October 12, 2023
    2:00 PM – 3:00 PM PDT
    Location: Exhibit Hall - Row H - Poster # 309

      Presenting Author(s)

    • HJ

      Han-Saem Jo

      researcher
      Yonsei university college of medicine
      seoul, United States

    • KS

      Kyu-Sik Shim

      researcher
      Yonsei university college of medicine, United States

      • Co-Author(s)

    • DR

      Da-Hye Ryu

      resident
      Yonsei university college of medicine, United States

    • DK

      Do-hyun Kim

      Researcher
      PLCOskin. Co. Ltd
      Seoul, Republic of Korea

    • GL

      Ga-Hye Lee

      Clinical researcher
      PLCOskin co.,ltd, United States

      • Primary Investigator(s)

    • JL

      Jung-Bok Lee

      Assistant Professor
      Sookmyung Women's University, Republic of Korea

      • Last Author(s)

    • WB

      Woo-Yeol Baek

      MD-PhD
      Yonsei university college of medicine, Republic of Korea

    Introduction:: Breast cancer patients suffer from lowered quality of life (QoL) after surgery. Breast conservancy surgery (BCS) such as partial mastectomy is being practiced and studied as an alternative to solve this problem. This study confirmed breast tissue reconstruction in a pig model by fabricating a 3-dimensional (3D) printed Polycaprolactone spherical scaffold (PCL ball) to fit the tissue resected after partial mastectomy.

    Materials and Methods:: A 3D printed Polycaprolactone spherical scaffold with a structure that can help adipose tissue regeneration was produced using computer-aided design (CAD). A physical property test was conducted for optimization. In order to enhance biocompatibility, collagen coating was applied and a comparative study was conducted for 3 months in a partial mastectomy pig model.

    Results, Conclusions, and Discussions:: In order to identify adipose tissue and fibroglandular tissue, which mainly constitute breast tissue, the degree of adipose tissue and collagen regeneration was confirmed in a pig model after 3 months. As a result, it was confirmed that a lot of adipose tissue was regenerated in the PCL ball, whereas more collagen was regenerated in the collagen-coated Polycaprolactone spherical scaffold (PCL–COL ball). In addition, as a result of confirming the expression levels of TNF-a and IL-6, it was confirmed that PCL ball showed higher levels than PCL–COL ball. Through this study, we were able to confirm the regeneration of adipose tissue through a 3-dimensional structure in a pig model. Studies were conducted on medium and large-sized animal models for the final purpose of clinical use and reconstruction of human breast tissue, and the possibility was confirmed.

    Acknowledgements (Optional): : This study was supported by the Ministry of Trade, Industry and Energy (MOTIE) and Korea Institute for Advancement of Technology (KIAT) through the International Cooperative R&D program. (Project No. P0019628).

    References (Optional): :