Professor of Molecular Engineering University of Chicago Chicago, Illinois, United States
Introduction:: Trained Immunity is a nascent area of innate immunity that involves the alteration of epigenetic and metabolic signatures of innate cells. To date, very little immunoengineering has been conducted on training systems. I will present my labs initial efforts to alter T training responses, to identify new pathways of training, and to provide broad prophylaxis against disease using training.
Materials and Methods:: I will present work on using high-throughput chemical discovery to identify a new class of training compounds. The administration of these compounds to induce immunological prophylaxis in cancer and infectious disease. I will focus on the basic biology of training mechanism confirming the epigenetic and metabolic alteration of the macrophages. I will present results showing the improvement in survival for infectious challenge against Listeria and tumor challenge of B16F10 melanoma.
Results, Conclusions, and Discussions:: We have concluded that there are multiple mechanisms for training that have previously remained unidentified. Using highthroughput discovery, we revealed multiple new forms of training with accompanied molecular systems. These new training methods can be used to induce altered states of innate response for broad prophylaxis against both infection and tumor growth.
