(H-317) Breast Tissue Restoration after the Partial Mastectomy UsingPolycaprolactone Scaffold

Introduction:: As breast conserving surgery increases in the surgical treatment of breast cancer, partial mastectomy is also increasing. Polycaprolactone (PCL) is a polymer that is used as an artifact in various parts of the human body based on the biocompatibility and mechanical properties of PCL. Here, we hypothesized that a PCL scaffold can be utilized for the restoration of breast tissue after a partial mastectomy.

Materials and Methods:: To demonstrate the hypothesis, a PCL scaffold was fabricated by 3D printing and three types of spherical PCL scaffold including PCL scaffold, PCL scaffold with collagen, and the PCL scaffold with breast tissue fragment were implanted in the rat breast defect model. The PCL scaffold in the present study was fabricated by a 3D printing procedure as shown in Scheme 1A.

Results, Conclusions, and Discussions:: After 6 months of implantation, the restoration of breast tissue was observed in the PCL scaffold and the expression of collagen in the PCL scaffold with collagen was seen. The expression of TNF- was significantly increased in the PCL scaffold, but the expression of IL-6 showed no significant difference in all groups. Through this, it showed the possibility of using it as a method to conveniently repair tissue defects after partial mastectomy of the human body.

Acknowledgements (Optional): : This study was supported by a faculty research grant of the Ministry of Trade, Industry and Energy (MOTIE) and Korea Institute
for Advancement of Technology (KIAT) through the International Cooperative R&D program. (Project No. P0019628).

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