Associate Professor Nova Southeastern University, United States
Introduction:: Inflammation testing through the process of flow assay, using TNF-α and IL-1β cytokines found in saliva, was evaluated. The market analysis of the study highlighted a vital need for an at-home testing device, to monitor inflammation and autoimmune diseases. The device targets psoriasis and arthritis inflammatory cytokines, via antibody binding.
Materials and Methods:: Modeling of the device was based on existing pregnancy and COVID-19 at-home testing technology. Antinuclear antibody (ANA) testing and infrared thermography were considered as viable options but proved to be insufficient for the customer needs. Design codes from the FDA for immunotoxicity testing were considered in the modeling and creation process.
Results, Conclusions, and Discussions:: A SolidWorks drawing of the low-density polyethylene testing holder, that encases the flow assay process was developed. The test was devised for disposal and total costs were $447.10; cost was under the predicted $600 limit for production, testing, and errors. 3-D printing of the device and physical testing in a laboratory will be done in the future.
